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'''{{DHSIHEAD}}
<br>'''Name: Olga  Gonchar,  Ph.D.'''
<br>'''Degree:''' Ph D, Biology (Specialization Physiology of Human and Animals)
<br>Bogomolets  Institute  of  Physiology  National  Academy  of  Sciences  of  Ukraine, 1996
<br>M.Sc.,  with honour,  Biology and Chemistry
<br>Taras Shevchenko  Pedagogical University of Lugansk, 1984

<br>'''Present position:'''
<br>Senior researcher, Department  of  Hypoxic  States,  Bogomolets  Institute  of  Physiology National  Academy  of  Sciences  of  Ukraine 

<br>'''Academic  and  professional  honours  and  awards:'''
<br>Grand  of  the  Forchungsgruppe “Neurohormonale Wirkungsmechanismen” der Sachsischen Academie  der  Wissenchaften  zu  Leipzig  an  der  Friedrich-Schiller-Universitat, Jena, 2002.
<br>Member  of  Ukrainian  Physiological   Society,   Member  of  Ukrainian  Pathophysiological Society

<br>'''Field of research:'''
<br>biochemistry, physiology, pathophysiology, cellular  and  molecular biology

<br>'''Practical Experience:''' Research of molecular and genetic mechanisms regulation of  prooxidant-antioxidant  homeostasis, energy metabolism and apoptosis   in  cells during the development of oxidative stress different genesis (immobilization, hypoxia of various origin, and cardio- and neurotoxins) as well as the role of intracellular thiols (glutathione and thioredoxin systems) and antioxidant enzymes (MnSOD, catalase, etc.) in cellular redox-potential  shaping and redox-signaling implementation. Study the peculiarities of compensatory-adaptive reactions formation involving redox-sensitive nuclear transcription factors under the various modes of interval hypoxic training, hypoxic and hypoxic-hyperoxic preconditioning, restrain stress. The correction of pathophysiological disorders by new pharmacological substances.

<br>'''Procedures and skills:'''
<br>-Animal handling experience (different models of intermittent hypoxic training and hypoxic  states   of  different genesis, stress exposures, physical exercises, drug intoxication in rats);
<br>- Isolation of  the       subcellular  fractions  of  rats  tissues (cytosol, mitochondria, lysosome, nucleus)  and  cells  of  blood; 
<br>- Assay of the content of lipid peroxidation products, activity of antioxidant enzymes, enzymatic  complexes of the respiratory  chain  in mitochondria and enzymes of different metabolic cycles;
<br>- determination of the glutathion and thioredoxin systems components (enzymatic and nonenzymatic);
<br>- western transfer and immunoblotting;
<br>- electrophoresis;
<br>- RNA isolation

<br>'''Key publications'''
#O Gonchar, I Mankovska.Moderate hypoxia/hyperoxia attenuates acute hypoxia-induced oxidative damage and improves antioxidant defense in lung mitochondria. Acta Physiol Hung. 2012, 99 (4), 436-446
#O Gonchar, I Mankovska. Antioxidant system in adaptation to intermittent hypoxia. J. Biol. Sci.2010, 10 (6), 545-554
#O Gonchar. Muscle fiber specific antioxidative system adaptation to swim training in rats: influence of intermittent hypoxia. J Sports Sci Med. 2005, 4 (2), 160-169.
#O Gonchar, I Mankovska. Effect of moderate hypoxia/reoxygenation on mitochondrial adaptation to acute severe hypoxia. Acta Biologica Hung. 2009, 60 (2), 185-194
#O Gonchar, I Mankovska. Glutathione system adaptation to acute stress in the heart of rats during different regimes of hypoxia training. Ukr. Biochem. J.1999, 79 (3), 79-85
#ОА Гончар, ЕВ Розова. Влияние разных режимов интервальных гипоксических тренировок на морфологические характеристики и антиоксидантный статус тканей сердца и легких.Бюл. Экспер. Биол. и Мед. 2007, 144 (8), 216-220
#YI Prylutskyy, IV Vereshchaka, AV Maznychenko, NV Bulgakova, O O Gonchar, OA Kyzyma, U Ritter, P Scharff, T Tomiak, D M Nozdrenko, I V Mishchenko, AI Kostyukov. C 60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue. J of nanobiotechnology . 2017, 15 (1), 1-8
#O Gonchar, I Mankovska. Hypoxia/Reoxygenation modulates Oxidative Stress Level and Antioxidative Potential in Lung Mitochondria: Possible participation of P53 and NF-KB Target Proteins. Arch Pulmonol Respir Care, 2017, 3(2):035-043
#O Gonchar, I Mankovska.Time-dependent effect of severe hypoxia/reoxygenation on oxidative stress level, antioxidant capacity and p53 accumulation in heart mitochondria. Ukr. Biochem. J. 2017, 89(6): 41-49
#Mankovska I. and Gonchar O. Response of mitochondrial thiol-redox systems to an oxidant challenge caused by acute hypoxia: protective effect of adaptation to hypoxia/hyperoxia. In: Adaptation Biology and Medicine. Eds. Laurentiu M. Popescu, A.R. Hargens and Pawan K Singal, Narosa Publishing House Pvt. Ltd., New Delhi, India, 2013, v.7, p. 169-181.

<br>'''Contact'''
<br>Bogomoletz Str, 01024 Kyiv, Ukraine 
<br>Department of Hypoxic States (office322)
<br>e-mail: olga.gonchar@i.ua 
<br>Phone +38044 256 24 92