Yaroslav M. Shuba

PhD, DSc, Professor of Biophysics

Current Position and Address

Chair of the Department of Neuromuscular Physiology
Bogomoletz Institute of Physiology (BIPh) of the National
Academy of Sciences of Ukraine (NASU),
4 Bogomoletz Street, Office 1101
01024 Kyiv-24, Ukraine
Tel./Fax:+380-44-2562435, E-mail: yshuba[at]biph.kiev.ua

Education and Degrees

• MS: Kiev State Shevchenko University, Kiev, USSR, 1977, Radiophysics
• PhD¹: Bogomoletz Institute of Physiology, Kiev, USSR, 1983, Biophysics
• DSc²: Bogomoletz Institute of Physiology, Kiev, USSR, 1991, Biophysics
• Research Director: Highest Attestation Committee of Ukraine, Kyiv, Ukraine, 2004, Biophysics
• Professor: Highest Attestation Committee of Ukraine, Kyiv, Ukraine, 2004, Biophysics

¹ PhD thesis (1983): "The effect of Ca²⁺-chelating agents on selectivity properties of voltage-gated Ca²⁺ channels"
² Doctor of Science (DSc) thesis (1991): "Voltage-gated Ca²⁺ channels: types, properties, pharmacology and regulation"

Academic Positions

• 2007-present: Chair, Department of Neuromuscular Physiology, BIPh NASU, Kyiv, Ukraine (primary appointment).
• 2007-2016: Deputy Director, Intl. Center of Molecular Physiology, NASU, Kyiv, Ukraine (secondary appointment).
• 2006-2007: Chair, Laboratory of Molecular Biophysics, BIPh NASU, Kyiv, Ukraine.
• 1983-2006: Junior Scientist, Scientist, Senior Scientist, Leading Scientist, BIPh NASU, Kiev/Kyiv, USSR/Ukraine.
• 1980-1983: PhD student, Kiev affiliate of Moscow Physical and Technical Institute, Kiev, USSR, 1980-83, Biophysics
• 1977-1980: Research Associate in Plasma Physics, Institute of Physics NASU, Kiev, USSR.

Visiting Positions

• 1998-2017: Invited Professor (up to 3 months/year), Laboratory of Cell Physiology, University de Lille 1
  Sciences and Technologies, Villeneuve d’Ascq, France.
• 2003/07/08/10/13: Invited Collaborator (up to 3 months/visit), Departments of Physiology and Biochemistry School of Medicine
  Universidad Central del Caribe, Bayamon, Puerto Rico, USA.
• 09/1993-09/1996: Research Assistant Professor, Department of Pharmacology, Georgetown University, Washington DC, USA
• 07/1991-08/1993: Visiting Scientist, Department of Physiology & Biophysics, Dalhousie University, Halifax, Canada .
• 10/1988-06/1989: Research Fellow, II Physiological Institute, University of Saarland, Homburg, Germany.

Teaching

• 1997-present: Courses on Electrophysiology and Biophysics of Ion Channels in Shevchenko National University,
  National Polytechnical Institute and National Mohyla Academy (Kyiv, Ukraine)

Honors and Awards

• 2003: Ukrainian State Prize in the field of Sciences and Technologies.
• 2010: Honor of excellence of the Ukrainian Parliament.
• 2013: P.G. Kostyuk Prize of the National Academy of Sciences of Ukraine.

Publications

See on PubMed

Books

Y.M. Shuba. The basics of molecular physiology of ion channels. Kyiv, “Naukova Dumka”, 2010. 448 pages [in Ukrainian].

Summary of Research Activities

Has been involved in the research of membrane ion channels in neuronal, cardiac and other cell types since 1980. Significantly contributed to the discovery of the phenomenon of Ca²⁺-dependent regulation of voltage-gated Ca²⁺ channels (VGCCs) selectivity and permeation (J. Membr .Biol, 1983, 76:83-93), description of neuronal VGCCs diversity (Pflügers Arch, 1988, 411:661-669), characterization of endogenous and recombinant low voltage-activated (LVA or T-type) Ca²⁺ channels (Neurosci, 1996, 70:729-738, Brain Res, 1998, 783:280-285, NeuroReport, 1999, 10:651-652; Pflügers Arch, 2001, 441:832-839, Biochem. Pharm, 2005, 69:841-854, BBA, 2007, 1768:1406-19, Cell Mol Life Sci, 2013, 70:1653-1661), developing of a kinetic model for VGCCs activation (J. Membr. Biol, 1989, 110:29-38, J. Physiol, 1991, 443:25-44), assessment of a direct, Gs protein-mediated pathway in β-adrenergic regulation of cardiac Ca²⁺ and Cl- channels (J. Physiol, 1990, 424:205-228, Am. J. Physiol, 1990, 259:H264-H267, Am. J. Physiol, 1997, 273:H2539-H2548), characterization of ß-adrenergic regulation of cardiac Na+-Ca²⁺ exchanger (Proc. Natl. Acad. Sci. USA, 1996, 93:5527-5532, J. Biol. Chem, 1998, 273:18819-18825), evaluation of pharmacological and hormonal regulation of cardiac K+ channels (J. Cardiovasc. Pharm, 1997, 30:42-45, J. Pharm. Exp. Ther, 1997, 281:233-244, Biochem. Pharm, 2001, 62:41-49, Br J Pharmacol, 2011, 162:701-11, BBA, 2012, 1821:1167-76), characterization of membrane conductances in prostate cancer epithelial cells and their roles in carcinogenesis (a number of publications since 2000).

Y. Shuba’s scientific career is closely associated with Bogomoletz Institute of Physiology (BIPh) of the National Academy of Sciences of Ukraine (NASU), Kyiv, Ukraine, where he began to do research in 1980 as PhD student, received his two scientific degrees (PhD in 1983 and DSc in 1991) and worked on different positions, from junior scientist to the head of the laboratory, till March, 2007. Since March, 2007 Y. Shuba chairs the Department of neuromuscular physiology at BIPh NASU. In 2007-2016 he also held secondary appointment as deputy Director of the International center of molecular physiology NASU. Y. Shuba’s current research is aimed at establishing alterations in ion channel-dependent mechanisms of the regulation of smooth muscle, particularly bladder smooth muscle, contractility in such pathological conditions as diabetes and cancer. During 1990s and 2000s Y. Shuba’s research was primarily focused on investigation of the diversity of LVA Ca²⁺ channels in central, particularly thalamic neurons, on characterization of pharmacology and permeation of various types of recombinant LVA channels, on pharmacology and regulation of various types of cardiac K+ channels with particular relevance to the endogenous and exogenous mechanisms of cardioprotection. During the period of 1993-96 Y. Shuba worked as Research Assistant Professor at Georgetown University (Washington, DC, USA) where in collaboration with Prof. M. Morad he studied the mechanisms of ß-adrenergic regulation of cardiac Na+-Ca²⁺ exchanger and pharmacology of cardiac K+ channels. After returning to his home institution he continued to carry fruitful collaborations with several foreign laboratories which generated a number of important publications in scientific literature: Laboratory of Cell Physiology at University of Lille1 (France) headed by Prof. N. Prevarskaya on characterization of membrane ion channels in prostate cancer epithelial cells and their involvement in carcinogenensis, laboratory of Prof. S. Skatchkov at Central Caribbean University (Puerto Rico, USA) on description of potassium conductance in glial cells, laboratory of Dr. M. Oz at United Arab University (Al Ain, UAE) on modulation of ion channels by endocannabinoids. Y. Shuba is very innovative; he developed two experimental techniques – double pipette technique for rapid dialysis of small cells (Pflüg. Arch, 1988, 415:767-773) and perfusion technique for Xenopus oocytes (Pflüg. Arch, 1996, 432:562-570). He was a recipient of several international research grants from International Science Foundation, Georgetown University, American Heart Association, Fogarty foundation and INTAS. He authored and co-authored a number of seminal reviews, wrote a handbook on molecular physiology of ion channels (in Ukrainian). His research is well known in the international scientific community.