Research Areas of the Institute
Institute of Physiology is a leading research institution in Ukraine in the fields of neuroscience, biophysics, molecular and cellular physiology. Our research covers a wide range of fundamental and applied topics aimed at understanding the mechanisms of body function in health and disease, as well as at developing novel approaches to diagnosis and treatment of disorders, including those arising as a consequence of warfare.
Molecular mechanisms of neurophysiological processes and neurodegeneration
- Molecular mechanisms underlying the antiepileptic action of gap junction inhibitors
- Interaction between GABA\(_A\) receptors and ASIC channels as a novel molecular target for the therapy of stress‑induced insomnia
- Investigation of the role of receptors and ion channels in intracellular signaling in neurons in models of Alzheimer’s disease and hypoxia
- Structural changes of the neurogenic niche in Alzheimer’s disease
- Molecular‑genetic mechanisms of neurodegenerative brain changes in a model of post‑traumatic stress disorder
- Molecular mechanisms of neurological disorders and possible ways of their correction
- Influence of neurotransmitters on calcium signaling in CNS neurons in health and disease
- Cellular and humoral mechanisms of neuroprotection in experimental models of brain injury (in vivo and in vitro)
- Development of an advanced technology for treating diabetic neuropathic pain using viral vectors
Biophysics and pharmacology of ion channels
- Pharmacological regulation of ligand‑ and mechano‑gated ion channels
- Role of mitochondrial mechanisms in the development and prevention of cardiovascular dysfunction during aging
- Redox‑dependent mechanisms of cardiovascular system alterations in aging and doxorubicin‑induced heart failure
Physiology of trauma, pain and recovery
- Study of descending regulation of sensory neuron activity in health and in chronic pain syndromes
- Cellular and molecular mechanisms of hypoxia in pathologies associated with combat trauma
- Development of methods for studying injuries and diseases in wartime and post‑war periods
Physiology of the immune and reproductive systems
- Mechanisms and ways to modulate regulated cell death in the immune system (thymus, lymph nodes) and reproductive system (ovaries, testes)
- Involvement of stress‑responsive systems in the development of local and systemic pathologies and in tissue regeneration
Neurophysiology of movement and sensorimotor coordination
- Central coordination of muscle activity in bi‑articular limb movements in mammals
- Development of methods for assessing arm movement control after wounds or injuries
Biomedical innovations and multidisciplinary approaches
- Biomedical Center for Innovative Research in Neuroscience
- Integration of fundamental physiology, molecular biology, biophysics and clinical research to create new therapeutic strategies
