Study of synaptic transmission between dorsal root ganglion (DRG) neurons and dorsal horn (DH) neurons in coculture

Study of synaptic transmission between dorsal root ganglion (DRG) neurons and dorsal horn (DH) neurons in coculture

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The quantal properties of neurotransmitter release in primary afferent synapses on dorsal horn neurons in co-culture were characterized (Shypshyna et al., 2011).

The contribution of pre- and postsynaptic mechanisms to the expression of long-term depression (LTD) in these synapses was elucidated (Shypshyna et al., 2013).

The role of Ca²⁺-permeable AMPA receptors in modulating paired-pulse depression (PPD) of glutamatergic neurotransmission in nociceptive sensory synapses was determined (Shypshyna et al., 2015).

A modulatory effect of peptide neuroprotectors on glutamatergic neurotransmission in synapses formed by sensory neurons on dorsal horn neurons was revealed in a model of short-term hyperglycemia (Shypshyna et al., 2015).