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Official site of the O.O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine
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04.03.2021 To the attention of the Institute staff and the concerned public


Contents

News

NEUROTWIN invites all scientists interested in Advanced Light and Electron Microscopy for Life Sciences to an online course by Sweden National Microscopy Infrastructure which will be held on September 22-24th. The course home-page: https://nmisweden.se/arkiv/4th-nmi-course-online.html Registration is required. Deadline September 20. For more info, please, contact Dr.Olga Nosova: olga.kononenko@farmbio.uu.se


NEUROTWIN Project invites you to the Bioseminar series of Uppsala University that will resume this Thursday, 9nd Sept 2021, 10:00. This week’s presenter is Dr. Joar Gutestam, who will give a lecture on “Neuroimaging of Addiction”. See you on Zoom https://uu-se.zoom.us/j/68209194308


NEUROTWIN Project invites you to the Bioseminar series of Uppsala University that will resume this Thursday, 2nd Sept, 10:00. This week’s presenter is Prof. Robert Fredriksson who will give a lecture on “The role of the vesicular polyamine transporter in regulation of memory and LTP”. See you on Zoom https://uu-se.zoom.us/j/68209194308


  • Dear colleagues! NEUROTWIN project partner - Professor Georgy Bakalkin (Molecular Neuropsychopharmacology Group, Department of Pharmacy and Biological Research, Uppsala University, Sweden) invites the Institute staff to a series of online seminars on biological sciences, which will be held on Thursdays. This week's speaker:

17.06.2021 (Thursday) 10.00 Iliana K Kerzeli (PhD Student, Immuno-oncology Research Group, Dept. of Pharmaceutical Biosciences): Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model Meeting ID: 637 4402 8735 Passcode: farmbio Join


  • 22.06.2021 - 03.07.2021 р. Odesa Mechnikov National University hold XVI International Summer School “Molecular Biology, Biotechnology and Biomedicine”. In frame of Summer School 5-6 july the Conference for young scientists will be held Information

  • Dear colleagues! NEUROTWIN project partner - Professor Georgy Bakalkin (Molecular Neuropsychopharmacology Group, Department of Pharmacy and Biological Research, Uppsala University, Sweden) invites the Institute staff to a series of online seminars on biological sciences, which will be held on Thursdays. This week's speaker:

27.05.2021 (Thursday) 10.00 Prof. Ulrika Simonsson (Department of Pharmaceutical Biosciences, Research group Translational Drug Discovery and Development): Preclinical evaluation of PK/PD of drug combinations Meeting ID: 637 4402 8735 Passcode: farmbio Join


History

O.O. Bogomoletz Institute of Physiology of National Academy of Sciences (NAS) of Ukraine was founded in 1953 as a result of the merging of the Institute of Experimental Biology and Pathology (IEBP) of the Ministry of Health of the Ukrainian SSR and the Institute of Clinical Physiology (ICP) of the Academy of Sciences of the Ukrainian SSR.

Both institutes were founded in 1931 - 1934 due to the initiative of Academician OO Bogomolets, a world-renowned scientist who was the director and supervisor of these two institutions until 1946. During 1946 - 1953, they managed the institutes of experimental biology and pathology and clinical physiology, respectively - O.O. Bogomolets and RE Kavetsky.

The scientific activity of the institutes was of great importance for the development of physiology. These institutes have studied and researched allergy, immunity, hypoxia, tumor development, and the most important issues of endocrinology, gerontology, and geriatrics. Based on the research of O.O. Bogomolets, original concepts that became important milestones in the development of some areas of physiology was created. These include connective tissue physiology, blood transfusion effects, body reactivity, cytotoxic sera, and more.

In 1953, A.M. Vorobyov, Corresponding Member of the National Academy of Sciences of Ukraine, became the newly established Institute of Physiology director. O.O. Worshipers. From 1956 to 1966, the Academician of the National Academy of Sciences of Ukraine AF Makarchenko headed the institute. During this time, departments of electrophysiology (headed by Academician DV Vorontsov), General Physiology (headed by Academician PG Kostyuk), Biophysics (headed by Corresponding Member of NASU AA Gorodetsky), Physiology of Aging were established. (Chairman - Doctor of Medical Sciences NV Lauer) and others.

From 1966 to 2010, the institute was headed by Academician of NASU PG Kostyuk. Since 2011, the Academician of NASU O.O. Krishtal is the director of the institute.

Academician PG Kostyuk and his students Kryshtal OO, Pidoplichko VI, Veselovsky MS and other collaborators were the first in the world to develop and apply intracellular soma dialysis methods to study the membrane and molecular mechanisms of nerve cell functions.


Research

O.O. Bogomolets Institute of Physiology is a research center in molecular physiology, biophysics, neurophysiology, and pathological physiology. For the first time in the former Soviet Union, microelectrodes were used at the institute to study the structural and functional organization of neural centers, biophysical and molecular mechanisms of neural excitation and inhibition. Academician PG Kostyuk and his students Kryshtal OO, Pidoplichko VI, Veselovsky MS and others developed and applied the methods of intracellular dialysis of the cell soma have been developed and applied to study the membrane and molecular mechanisms of cells' neural functions. New data on physical and chemical processes in nerve and muscle cells, synaptic transmission mechanisms, and ionic mechanisms of excitation were obtained. The order of participation and response to stimuli by different groups of cortical neurons and the mechanisms of inhibitory processes in the cerebral cortex were identified.

The modulating effect of different parts of the brain on cardiovascular reflexes, the relationship between central and peripheral mechanisms of vascular tone regulation under functional load were determined. Original models of acute myocardial dystrophy leading to shock have been developed. Important data were obtained on immunogenic disorders of the cardiovascular system.

A new set of methods for determining the effectiveness, condition, and level of athletes' training, methods of functional diagnosis of cardiovascular and respiratory diseases were developed. New methods of studying higher human nervous activity have been proposed, and appropriate equipment has been developed. Studies were conducted to determine the intensity of work, to develop physiological criteria for professional selection. A method of optimizing the dose of mineral water "Naftusya" was developed, which increased the effectiveness of spa treatment of kidney and liver diseases.

The Institute has a postgraduate course

Documents are accepted from June 25 to September 10.

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