Department of Cellular Membranology - Історія редагувань

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2020-10-25T23:06:45Z

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Siva: /* Members */

2020-01-22T13:39:25Z

Members

Siva: /* Members */

2020-01-22T13:38:52Z

Members

Siva: /* Publications */

2020-01-22T12:43:17Z

Publications

Siva: /* Members */

2020-01-22T12:42:22Z

Members

Siva: /* Technical staff and secretary */

2020-01-22T12:41:20Z

Technical staff and secretary

Siva: /* Research staff */

2020-01-22T12:40:32Z

Research staff

Siva: /* Methods */

2020-01-22T12:38:52Z

Methods

Siva: /* Methods */

2020-01-22T12:38:23Z

Methods

Siva: /* Our research */

2020-01-22T12:34:21Z

Our research

← Попередня версія		Версія за 13:39, 22 січня 2020
Рядок 76:		Рядок 76:
	Olena Kotyk - junior researcher		Olena Kotyk - junior researcher

−	Artem Venhreniuk	+	Artem Venhreniuk - engineer

@@ Рядок 25: / Рядок 25: @@
 ='''Members'''=
 Prof. Oleg Krishtal - the head of department, PhD, DSc, Professor, Member of Academia Europaea, Full Member of the National Academy of Sciences of Ukraine
@@ Рядок 76: / Рядок 75: @@
 Olena Kotyk - junior researcher
 Artem Venhreniuk

@@ Рядок 98: / Рядок 98: @@
 ='''Publications'''=
-* Tesoriero, C; Codita, A; Zhang, MD; Cherninsky, A; Karlsson, H; Grassi-Zucconi, G; Bertini, G; Harkany, T; Ljungberg, K; Liljestrom, P; Hokfelt, TGM; Bentivoglio, M; Kristensson, K H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep-wake regulatory neurons in mice Proceedings Of The National Academy Of Sciences Of The United States Of America, 113 (3), 2016, E368-E377 (DOI: 10.1073/pnas.1521463112,   IФ 9,75)
-* McGarvey L.P., Butler C.A., Stokesberry S., Polley L., McQuaid S., Abdullah H., Ashraf S., McGahon M.K., Curtis T.M., Arron J., Choy D., Warke T.J., Zholos, A Bradding P., Ennis M., Costello R., Heaney L.G.Increased expression of bronchial epithelial transient receptor 1 potential vanilloid 1 channels in severe asthma Journal of Allergy and Clinical Immunology 133 (3), 2014, 704-712 (DOI: 10.1016/j.jaci.2013.09.016,  IФ 12, 49)
+Li, HS; Su, XY; Song, XL; Qi, X; Li, Y; Wang, RQ; Maximyuk, O; Krishtal, O; Wang, TT; Fang, HQ; Liao, LJ; Cao, H; Zhang, YQ; Zhu, MX; Liu, MG; Xu, TL [https://doi.org/10.1523/JNEUROSCI.0213-19.2019 Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity] // JOURNAL OF NEUROSCIENCE, 39 (29), 2019,  P. 5773-5793 [https://doi.org/10.1523/JNEUROSCI.0213-19.2019 DOI: 10.1523/JNEUROSCI.0213-19.2019]
-* Krishtal O  Receptor for protons: First observations on Acid Sensing Ion Channels NEUROPHARMACOLOGY, 94, 2015, 4-8 (DOI: 10.1016/j.neuropharm.2014.12.014, IФ 5,10)
-* Ievglevskyi, D Isaev, O Netsyk, A Romanov, M Fedoriuk, O Maximyuk, E Isaeva, N Akaike, O Krishtal Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy The Royal Society Phil. Trans. R. Soc. B, 2016, 371(1700). pii: 20150431 (DOI: 10.1098/rstb.2015.0431, IФ 7,06)
-* Andriy Buta, Oleksandr Maximyuk, Dmytro Kovalskyy, Volodymyr Sukach, Mykhailo Vovk, Dmytro Isaev, Oleksandr Ievglevskyi, Elena Isaeva, Alina Savotchenko, Oleg Krishtal Novel potent orthosteric antagonist of ASIC1a prevents NMDAR-dependent LTP induction J Med Chem. 2015 Jun 11;58(11):4449-61.  (DOI: 10.1021/jm5017329,  IФ 6, 26)
+Rybachuk, O; Kopach, O; Pivneva, T; Kyryk, V  [https://doi.org/10.21769/BioProtoc.3165 Isolation of Neural Stem Cells from the Embryonic Mouse Hippocampus for in vitro Growth or Engraftment into a Host Tissue] // BIO-PROTOCOL, 9 (4), 2019, Article Number: e3165 [https://doi.org/10.21769/BioProtoc.3165 DOI: 10.21769/BioProtoc.3165]

@@ Рядок 24: / Рядок 24: @@
 ='''Members'''=
-==Research staff==
 Prof. Oleg Krishtal - the head of department, PhD, DSc, Professor, Member of Academia Europaea, Full Member of the National Academy of Sciences of Ukraine
@@ Рядок 76: / Рядок 77: @@
 Olena Kotyk - junior researcher
 ''Technical stuff and secretary''
 Artem Venhreniuk
 ''PhD students''
 Sofiia Demchenko

← Попередня версія		Версія за 12:41, 22 січня 2020
Рядок 93:		Рядок 93:

	Iuliia Nesterenko		Iuliia Nesterenko
−
−	~~==Technical staff and secretary==~~
−	* Liudmila Smolina

	='''Publications'''=		='''Publications'''=

@@ Рядок 25: / Рядок 25: @@
 ='''Members'''=
 ==Research staff==
-* Prof. Oleg Krishtal - the head of department, PhD, Dsc, Professor, Member of Academia Europaea, Full Member of the National Academy of Sciences of Ukraine
-* Dr. Oleksandr Maximyuk - leading researcher, PhD
+Prof. Oleg Krishtal - the head of department, PhD, DSc, Professor, Member of Academia Europaea, Full Member of the National Academy of Sciences of Ukraine
-* Dr. Maksym Storozhuk - leading researcher, PhD, Dsc
-* Dr. Olena Isaeva - leading researcher, PhD, Dsc
+Dr. Oleksandr Maximyuk - leading researcher, PhD
-* Dr. Dmytro Isaev - leading researcher, PhD
-* Dr. Ihor Chizhmakov - senior researcher, PhD
+Dr. Maksim Storozhuk - leading researcher, PhD, Dsc
-* Dr. Andrii Cherninskyi - senior researcher, PhD
-* Dr. Anna Kotliarova - senior researcher, PhD
+Dr. Dmytro Isaev - leading researcher, PhD
-* Tetiana Volkova - researcher
-* Dr. Vadym Sydorenko - researcher, PhD
+Dr. Ihor Chizhmakov - senior researcher, PhD
-* Andrii Buta - researcher
-* Dr. Alina Savotchenko - researcher, PhD
+Dr. Andrii Cherninskyi - senior researcher, PhD
-* Dr. Olena Iegorova - researcher, PhD
-* Dr. Viacheslav Kulyk - researcher, PhD
+Dr. Anna Kotliarova - senior researcher, PhD
-* Liudmila Nikolaenko - junior researcher
-* Olha Zapukhliak - junior researcher
+Dr. Alina Savotchenko - researcher, PhD
-* Volodymyr Khmyz - junior researcher
-* Yurii Tkachenko - junior researcher
+Dr. Olena Iegorova - researcher, MD, PhD
-* Artur Romanov - junior researcher
-* Oleksii Lunko - junior researcher
+Dr. Viacheslav Kulyk - researcher, PhD
-* Ruslan Bogovyk - junior researcher
-* Mykhailo Fedoriuk - junior researcher
+Dr. Oksana Rybachuk - researcher, PhD
-* Olena Kotyk - junior researcher
 ==Technical staff and secretary==

@@ Рядок 19: / Рядок 19: @@
 * a wide range of behavioral tests (open field, different mazes, Morris water maze, etc) that allow us to study general locomotor activity, anxiety and depression-like behavior, learning and memory, social behavior, etc.
-[[File:Depcm2020.png]]
+[[File:Depcm2020.png|border|800px]]
 Collage (clockwise): ''The effect of ASIC1a inhibition on hippocampal LTP (Buta A et. al, J. Med. Chem. 2015); patch-clamp technique (V. Kulyk); confocal microscopy of neural stem cell culture and neurospheres - astrocytes are red, neurons blue (O. Rybachuk); brain structures' LFPs in freely moving rat and it's spectrogram (R. Bohovyk); meeting colleagues at FENS Forum (A. Cherninskyi and E. Knapska); making artificial cerebrospinal fluid (O. Iegorova); central — specimens' microscopy (M. Fedoriuk).''

@@ Рядок 10: / Рядок 10: @@
 ='''Methods'''=
-Highly qualified Departments’ staff has a strong expertise in virtually all electrophysiological techniques, various disease models and cell/tissue cultural techniques allowing studying physiological functions and some pathologies from molecular to system levels including:
-* pharmacological patch clamp studies of different ion channels in acutely isolated cells (pyramidal neurons from hippocampus, cortex and hypothalamus; Purkinje and granule neurons from cerebellum; spinal dorsal horn neurons; primary sensory neurons; glial cells), cultured cells (the same as above; cancer cell lines) and heterologous expression systems (HEK293, CHO and PC-12 lines)
+Highly qualified Departments’ staff has strong expertise in virtually all electrophysiological techniques, various disease models and cell/tissue cultural techniques allowing studying physiological functions and some pathologies from molecular to system levels including:
-* registration of electrical activity of single neurons, local field potentials, EEG in freely behaving animals
+* pharmacological patch-clamp studies of different ion channels in acutely isolated cells (pyramidal neurons from hippocampus, cortex, and hypothalamus; Purkinje and granule neurons from cerebellum; spinal dorsal horn neurons; primary sensory neurons; glial cells), cultured cells (the same as above; cancer cell lines) and heterologous expression systems (HEK293, CHO, and PC-12 lines);
-* electrophysiological studies of primary nociception ex vivo and in vivo
+* registration of electrical activity of single neurons, local field potentials, EEG in freely behaving animals;
 * seizure-like activity in acute isolated and cultured brain slices in various models of epilepsy as well as intracranial EEG in various in vivo models of epilepsy;
-* wide range of behavioral tests (open field, different mazes, Morris water maze, etc) that allow us to study general locomotor activity, anxiety and depression-like behavior, learning and memory, social behavior, etc
+* a wide range of behavioral tests (open field, different mazes, Morris water maze, etc) that allow us to study general locomotor activity, anxiety and depression-like behavior, learning and memory, social behavior, etc.
 ='''Members'''=

@@ Рядок 1: / Рядок 1: @@
 ='''Our research'''=
-Our Department research is focused on the role of membrane proteins, mainly ion channels and metabotropic receptors, in functioning of single neurons, neural networks and the whole organs. The current research areas of the Department are:
+Our Department research is focused on the role of membrane proteins, mainly ion channels and metabotropic receptors, in the functioning of single neurons, neural networks, and the whole organs. The current research topics of the Department are:
-* biophysical and pharmacological properties of ion channels and receptors of cellular membranes;
+* biophysical and pharmacological properties of ion channels and receptors of cellular membranes (plasmalemma and nuclear envelope);
 * molecular mechanisms of epilepsy and epileptogenesis and pharmacological agents with antiseizure properties;
 * role of membrane receptors and ion channels in synaptic plasticity, learning, integral activity of nervous system and behavior;
 * peripheral and central mechanisms of pain and possible ways of its correction;
 ='''Methods'''=