Department of Biophysics of Ion Channels

Bogomoletz Institute of Physiology
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General information

Відділ біофізики іонних каналів

The Department of Biophysics of Ion Channels was established in June 2017 from the laboratory of the same name, which was established in April 2012 based on the staff of the Department Department of General Physiology of the Nervous System . The main research subjects in recent years have been the mechanisms of regulation of intracellular concentration of Ca2 + and calcium signaling in nerve and neuroendocrine cells. Experiments use neurons that are isolated or in culture, as well as brain sections. Digital and confocal microscopy), electrophysiological (patch clamp), genetic (PCR), behavioral and mathematical (mathematical modeling). The Department conducts fundamental and applied research in the field of neurophysiology and biophysics. The main attention is paid to intracellular signaling with special emphasis on the study of ion channels. The mechanisms of occurrence and course of such diseases of the nervous system as ischemia, Alzheimer's disease, epilepsy, and neuropathy are studied. Head of the Department prof., DrSci. Elena A Lukyanetz.

Scientific research

Staff of the Department

Employees

  1. Lukyanetz Olena Oleksandrivna - Doctor of Science, Professor, Head of the Department 212, 1430, 2562430
  2. Magura Igor Silvestrovich - Doctor of Science, Professor, Academician, Prov.Ns., 219, 1424, 2562424
  3. Melnyk Igor Vasyliovych - Doctor of Science, Prov.Ns., 220, 1093 2562093
  4. Shkryl Vyacheslav Mikhailovich - Ph.D., senior researcher, 220, 1093 2562093
  5. Pogorela Nelya Hrystoforivna - Ph.D., 221, 1425, 2562425,
  6. Rozumna Natalia Mykolayivna - Ph.D., senior researcher 1007 1460, 2562460
  7. Petrushenko Olena Anatoliivna - Ph.D. Assoc., 201, 1594, 2562594
  8. Tarasenko Alexander Nikolaevich - Ph.D. Assoc., 406, 1036, 2562036
  9. Yavorsky Volodymyr Antonovych - Ph.D. Assoc., 201, 1594, 2562594
  10. Lukyanets Igor Oleksandrovych - researcher, 213, 1427, 2562427
  11. Ganzha Vita Viiktorivna - M.Sc., 218, 1595, 2562595,
  12. Gorbachenko Vasyl Anatoliyovych - M.Sc. 211 1427 2562427
  13. Petrushenko Maria Oleksandrivna - M.Sc. 215 1594 2562594
  14. Chentsova Ilona Ivanivna - M.Sc., 211, 1421, 2562421,
  15. Vrublevsky Serhiy Vitaliyovych - lane engineer, 16, 1598, 2562598,
  16. Burlak Maryana Petrovna - lane engineer, 218, 1595, 2562595,
  17. Tishchenko Yuliya Mykolayivna - eng., 218, 1595, 2562595,
  18. Drobna Olena Leontiivna - eng., 221, 1425, 2562425,
  19. Sotkis Lyudmyla Valentynivna - lab. with acting 215 1433, 2562433,
  20. Kraysvitniy Oleksandr Ivanovych - PhD student 201, 1594, 2562594,
  21. Omelchuk Anna Oleksandrivna - PhD student 218, 1595, 2562595,



Our former associates around the world
Oleh M. Pochynyuk, Ph.D.
Ruslan Stanika, PhD
Sergiy Tokar, PhD
Oleg Zaika, PhD
Anastasiia Stratiievska, Ph.D.
Yevheniia Kravenska, PhD

Дослідна діяльність

Основні напрямки досліджень

  • вивчення внутрішньоклітинних процесів розвитку нервових захворювань (ішемія мозку, хвороба Альцгеймера, епілепсія) та пошук засобів нейропротекції
  • вивчення механізмів секреції та синаптичної передачі

Об’єкти досліджень

  • тварини (щури),
  • культури клітин (первинні та довготривалі культури клітин)

Методи досліджень

  • моделювання нейродегенеративних станів in vivo (церебральна ішемія, хвороба Альцгеймера, епілепсія, нейропатії) та in vitro (церебральна ішемія, хвороба Альцгеймера, епілепсія);
  • електрофізіологія
  • амперометрія
  • полярографія
  • онлайн мікрофлуоресцентна мікроскопія
  • мікроскопія: світлова, флуоресцентна, конфокальна, електронна,
  • методи імуногістохімії
  • зворотня транскрипція та полімеразна ланцюгова реакція (ПЛР),
  • поведінкові реакції
  • математичне моделювання

Наукові досягнення. Вибрані публікації

See on SCOPUS or PUBMED

  • T.Rothea, M.Delianoa, A.M.Wójtowiczb, A.Dvorzhak, D.Harnack, S.Paulb, T.Vagnerb, I..Melnick, H.Starka R.Grantyn Pathological gamma oscillations, impaired dopamine release, synapse loss and reduced dynamic range of unitary glutamatergic synaptic transmission in the striatum of hypokinetic Q175 Huntington mice.Neuroscience, 2015, 311, 519-538 (https://www.sciencedirect.com/science/article/abs/pii/S0306452215009586, IF 3.277)
  • I Niespodziany, EA Lukyanetz, A Matagne, H Klitgaard, C Wolff Brivaracetam does not modulate the major ionic conductances in neurons. EPILEPSIA, 2015, 56, 192-193 (https://insights.ovid.com/epilepsia/epil/2015/02/001/brivaracetam-does-not-modulate-major-ionic/585/00003606, 5,295)
  • Figueroa L, Shkryl VM, Blatter LA, Rios E. Using two dyes with the same fluorophore to monitor cellular calcium concentration in an extended range. PLoS One. 2013;8(2):e55778. (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055778, IF 3.73)
  • Shkryl VM, Blatter LA. Ca(2+) release events in cardiac myocytes up close: insights from fast confocal imaging.PLoS One. 2013 Apr 18;8(4):e61525. (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061525? IF 3.73
  • Lukyanets IA, Lukyanetz EA. Modulation of calcium signalling by the endoplasmic reticulum in Carassius neurons. Biochem Biophys Res Commun. 2013 Apr 19;433(4):591-4. (https://www.sciencedirect.com/science/article/pii/S0006291X13004506, IF 2,41)
  • EV Kravenska, VV Ganzha, EN Yavorskaya, EA Lukyanetz(2016) Effect of Cyclosporin A on the Viability of Hippocampal Cells Cultured under Conditions of Modeling of Alzheimer’s Disease. Neurophysiology 48 (4), 1-6 [1].
  • VA Yavorsky, EA Lukyanetz (2016) Serial Ramp Recordings for Rapid Testing of Generating Capacity of Isolated Hippocampal Neurons. International Journal of Physiology and Pathophysiology 7 (2), p. 167-177 [2].
  • A.V. Dragan, O.A. Petrushenko, O.P. Burlak E.A. Lukyanetz.(2016) EFFECT OF TRPA1 RECEPTOR ACTIVATION ON TRPV1 CHANNEL DESENSITIZATION IN RAT DORSAL GANGLION NEURONS. Fiziol. Zh. 2016; 62(1): 16-24. [3]
  • I Niespodziany, EA Lukyanetz, A Matagne, H Klitgaard, C Wolff (2015) BRIVARACETAM DOES NOT MODULATE THE MAJOR IONIC CONDUCTANCES IN NEURONS. EPILEPSIA 56, 192-193.[4]
  • V.A. Gorbachenko, J.O. Kruchenko, I.S. Chereda, E.A. Lukyanetz (2015) Measurements of the time parameters of conditioned food reflex in rats under memantin treatment with using of automatic registration system. Bulletin of National Taras Shevchenko University of Kyiv. Radio Physics and Electronics. 6(21),
  • Yavorsky VA, Lukyanetz EA. (2015) USING THE SERIAL RAMP RECORDINGS FOR RAPID TESTING OF THE GENERATING ABILITY OF IMPULSE ACTIVITY OF ISOLATED HIPPOCAMPAL NEURONS. Fiziol Zh. 2015;61(3):19-27.[5]
  • Kruchenko ZA, Gorbachenko VA, Chereda IS, & Lukyanetz EA (2014). Effect of Memantine on Motor Behavioral Phenomena in Rats of Different Ages. Neurophysiology 46, 448-451.[6]
  • Внутрішньоклітинний кальцієвий гомеостаз сенсорних нейронів при гіпоксичних впливах. Фізіол. журн., 2003, Т. 49, №3, c. 3-10. [7]

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