Mankovska Irina

Bogomoletz Institute of Physiology
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IRYNA M. MANKOVSKA


NAME: IRYNA M. MANKOVSKA, MD, PhD
PERSONAL:
Date of birth: May, 01, 1941.
Place of birth: Kiev, Ukraine.
EDUCATION AND SCIENTIFIC DEGREES:
1964: Graduated from the Kiev Medical Institute.
1969: Degree: Candidate of Medical Sciences (corresponding to PhD in Pathophysiology). Defended the thesis on “Investigation of functional and macrostructural state of myosin under muscle neuro-distrophy” at Kiev Medical Institute.
1986: Degree: Doctor of Medical Sciences (corresponding to MD). Defended the thesis on “Mas-transfer and utilization of Oxygen in muscle tissue, age-related peculiarities of the muscle tissue hypoxia development” at Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine.
2008: Professor.
Scientific Supervisor of 9 PhD thesis and Scientific Advisor of 2 DSc thesis.
AWARDS:
STATE PRIZE OF UKRAINE FOR SCIENCE AND TECHNOLOGY (2000);
THE DIPLOMA OF COUNCIL OF MINISTERS OF UKRAINE (2004);
THE DIPLOMA OF SUPRIME COUNCIL OF UKRAINE (2009)

POSITIONS:
2016- present: Leading Researcher, Department of Hypoxia, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kiev, Ukraine.
2003 – 2016: Head, Department of Hypoxia, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kiev, Ukraine.
1988 – 2003: Leading Researcher, Department of Hypoxia, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kiev, Ukraine.
1979 – 1988: Senior Researcher, Department of Hypoxia, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kiev, Ukraine.
1970 – 1979: Junior Researcher, Department of Hypoxia, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kiev, Ukraine.
1965 – 1970: Assistant of the Chair of Pathophysiology of the Kiev Medical Institute, Kiev, Ukraine.
SCIENTIFIC DIRECTIONS:
1. Developed the new approach to the oxygen regimen of muscle tissue investigation in terrestrial and marine mammals.
2. Revealed the age-related peculiarities of the muscle tissue hypoxia development.
3. Revealed the key links of relationship between the disturbances of energetic metabolism and free radical processes activation in different tissues under hypoxia.
4. Studied mechanisms of pathogenetic correction of tissue hypoxia by common use of biomembrane stabilizators and antioxidants.
5. Studied the methods of adaptation to hypoxia for prevention and correction of hypoxic disorders (high altitude stay and intermittent hypoxic training) and their use in medicine and sports.
6. Studied the genetic and epigenetic mechanisms of the oxygen-dependent cell processes regulation under adaptation to hypoxia and oxidative stress of different types.
7. Experimental and clinical (Parkinson’s disease and Diabetes mellitus) investigation of mitochondrial dysfunction development under hypoxia and oxidative stress: disturbances of mitochondrial structure, dynamics, energetic metabolism, ion homeostasis, redox balance.


KEY PUBLICATIONS
1. Drevytska T, Dosenko V, Nagibin V and Mankovska I. HIF-1α, HIF2α, HIF3α and HIF1β mRNA expression changes in different tissues under intermittent training. In: Ley Xi, Serebrovskaya TV, eds., Intermittent Hypoxia, Nova Science Publishers, Inc, N Y, USE, 2009: Chapter 21, 451-469.
2. Iryna Mankovska, Bronislav Gavenauskas, Valentyna Nosar, Olga Gonchar, Larisa Bratus, Nataliya Kurhalyuk. Effects of intermittent hypoxia on oxygen-dependent processes in skeletal muscle under endurance training In: Ley Xi, Serebrovskaya TV, eds., Intermittent Hypoxia, Nova Science Publishers, Inc, N Y, USE, 2009: Chapter 27, P 549-563.
3. I.Mankovska and O.Gonchar. Response of Mitochondrial Thiol-redox Systems to an Oxidant challenge caused by acute Hypoxia: Protective effect of adaptation to hypoxia/hyperoxia. In:Adaptation Biology and Medicine. Volume 7: NeW Challenges. Ed.L.M.Popescu, A.R.Hargens, P/K/Singal. Narosa Publishing House. New Delhi, 2014. – P.167-179.
4. Gonchar O, Mankovska I. Hypoxia/Reoxygenation modulates Oxidative Stress Level and Antioxidative Potential in Lung Mitochondria: Possible participation of P53 and NF-KB Target Proteins. Arch Pulmonol Respir Care. 2017, 3(2): 035-043.
5. Е.В.Розова, И.Н.Маньковская, Н.В.Карасевич, И.Н.Карабань. Митохондриальная дисфункция как характеристика полиорганной патологии при болезни Паркинсона: клинико-экспериментальное исследование // В сб. «Болезнь Паркинсона и расстройства движений». Руководство для врачей, ч. I., Москва, 2017. – С.42-45.
6. Гіпоксія як метод підвищення адаптаційної здатності організму. за загальною редакцією В.Г.Сліпченко, О.В.Коркушко. Співавтор Маньковська І.М. Київ: НТУУ „КПІ”, 2015. – 482с.


Hobby: English detective stories
Partisipation at the Frolkis Club for Kiev’s Scientists and creative workers
e-mail: mankovsk@biph.kiev.ua

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