NMP:History

Інститут фізіології ім. О. О. Богомольця
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Department
of Nervous
& Muscular
Physiology

History

Department's
history
M.F. Shuba (1928-2007)

The Department of neuro-muscular physiology (DNMP) was established in 1969. Its organizer and the only chair until 2007 was the founder of the Ukrainian national school for the study of smooth muscles, professor, full member of the National Academy of Sciences of Ukraine (since 1990) Michael F. Shuba (1928-2007). Smooth muscles represent one of the three types of muscular tissue of higher organisms, which are known to be divided into skeletal, cardiac and smooth. The latter forms the contractile apparatus of the walls of all internal hollow organs - vessels, stomach, intestine, bladder, uterus. At the time of the establishment of the Department, the studies on cardiac and skeletal muscles were already quite advanced, while understanding of smooth muscle functions were still at the stage of development. The main directions of research of the Department became:

  • elucidation of ionic mechanisms of electrogenesis and contraction of various types of smooth muscles;
  • identification of intracellular signaling pathways involved in excitation-contraction coupling in smooth muscle;
  • establishment of the neurotransmitter nature of excitation-inhibition and contraction-relaxation of various types of smooth muscle.

Under Prof. M.F. Shuba's lead the Department has become an internationally recognized center for the study of smooth muscle, in which discoveries of world significance were made, among which:

  • the establishment of the electrical connection between the individual smooth muscle cells, enabling the entire smooth muscle tissue to function as uninterrupted electrical syncytium ( see relevant publications ►);
  1. Шуба МФ. Влияние адреналина на электротон гладких мышц. Физиол Журн СССР им Сеченова, 1961; 47(8):109-13.
  2. Шуба МФ. Влияние ионов натрия на физический электротон гладких мышц. Биофизика, 1962; 7:193-200.
  3. Шуба МФ. Вплив ацетилхоліну на фізіологічний електротон гладеньких м’язів. Фізіол журн., 1962; 8:449-55.
  4. Шуба МФ. До проблеми спонтанної активності гладеньких м’язів. Фізіол журн., 1963; 9(1):48-55.
  5. Артеменко ДП, Шуба МФ. Метод дослідження електричних властивостей нервових та м'язових волокон при допомозі зовнішніх поверхневих електродів. Фізіол журн., 1964; 10:403-7.
  6. Шуба МФ. Об электрических свойствах гладких мышц. Биофизика, 1965; 10:64-71.
  7. Воронцова Д., Шуба МФ. Физический електротон нерва и мьшцы. Киев, Нукова думка, 1966, 216 с.
  8. Шуба МФ, Клевець МЮ. Іонні механізми гальмівної дії адреналіну та норадреналіну на гладеньком’язові клітини. Фізіол журн., 1967; 13(1):3-11.
  9. Шуба МФ. Електрофізіологічні властивості гладеньких м’язів. Фізіол журн., 1969; 15(2):211-21.
  10. Boev KK, Shuba MF, Taranenko VM. Physical electrotone from the smooth muscle of cat stomach. Izv Inst Fiziol (Sofiia), 1970; 13:251-6
  11. Boev KK, Shuba MF, Taranenko VM. Physical electrotone from the smooth muscle of cat stomach. Izv Inst Fiziol (Sofiia), 1970; 13:251-6
  12. Shuba MF. The mechanism of the excitatory action of catecholamines and histamine on the smooth muscle of guinea-pig ureter. J Physiol., 1977; 264(3):853-64.
  13. Shuba MF. The effect of sodium-free and potassium-free solutions, ionic current inhibitors and ouabain on electrophysiological properties of smooth muscle of guinea-pig ureter. J Physiol., 1977; 264(3):837-51.
  14. Шуба МФ, Кочемасова НГ. Физиология сосудистых гладких мышц. Киев, Нукова думка, 1988, 252 с.
  15. Шуба МФ, Гокина НИ, Гурковская АВ. Механизмы возбуждения и сокращения гладких мышц мозговых сосудов. Киев, Нукова думка, 1991, 168 с.
  • the discovery of polypeptide component from bee venom, apamine, as a potent and reversible modulator of neuromuscular synaptic transmission (inhibition) in the smooth muscle of gastrointestinal tract ( see relevant publications ►);
  1. Владимирова И, Шуба МФ. Влияние стрихнина, гидразина и апамина на синаптическую передачу в гладких мышцах. Нейрофизиология, 1978; 10:295-9.
  2. Shuba MF, Vladimirova IA. Effect of apamin on the electrical responses of smooth muscle to adenosine 5'-triphosphate and to non-adrenergic, non-cholinergic nerve stimulation. Neuroscience, 1980; 5(5):853-9.
  • determination of the contributions of extracellular calcium entry and intracellular calcium release in the activation of contraction and basal tone maintenance in different types of smooth musculature ( see relevant publications ►).
  1. Ganitkevich VYa, Shuba MF, Smirnov SV. Potential-dependent calcium inward current in a single isolated smooth muscle cell of the guinea-pig taenia caeci. J Physiol., 1986; 380:1-16.
  2. Ganitkevich VYa, Shuba MF, Smirnov SV. Calcium-dependent inactivation of potential-dependent calcium inward current in an isolated guinea-pig smooth muscle cell. J Physiol., 1987; 392:431-49.
  3. Бурый ВА, Гурковская АВ, Гокина НИ, Шуба МФ. Роль внутри- и внеклеточного кальция в активации сокращения гладких мышц легочной артерии серотонином. Бюл Экспер Биол Мед., 1988; 106(9):261-4.
  4. Ganitkevich VYa, Shuba MF, Smirnov SV. Saturation of calcium channels in single isolated smooth muscle cells of guinea-pig taenia caeci. J Physiol., 1988; 399:419-36.
  5. Ganitkevich VYa, Shuba MF, Smirnov SV. Inactivation of calcium channels in single vascular and visceral smooth muscle cells of the guinea-pig. Gen Physiol Biophys., 1991; 10(2):137-61.
  6. Zholos AV, Baidan LV, Shuba MF. The inhibitory action of caffeine on calcium currents in isolated intestinal smooth muscle cells. Pflugers Arch., 1991; 419(3-4):267-73.
  7. Жолос АВ, Шуба МФ. Регенеративное кальций-индуцированное освобождение кальцыя из внутриклеточных депо в гладкомышечных клетках. Докл Акад Наук СССР, 1991; 317(3):735-8.
  8. Zholos AV, Baidan LV, Shuba MF. Properties of the late transient outward current in isolated intestinal smooth muscle cells of the guinea-pig. J Physiol., 1991; 443:555-74.
  9. Smirnov SV, Zholos AV, Shuba MF. Potential-dependent inward currents in single isolated smooth muscle cells of the rat ileum. J Physiol., 1992; 454:549-71.
  10. Smirnov SV, Zholos AV, Shuba MF. A potential-dependent fast outward current in single smooth muscle cells isolated from the newborn rat ileum. J Physiol. 1992 Aug;454:573-89.
  11. Zholos AV, Baidan LV, Shuba MF. Some properties of Ca2+-induced Ca2+ release mechanism in single visceral smooth muscle cell of the guinea-pig. J Physiol., 1992; 457:1-25.
  12. Shapovalov AN, Shuba MF. Activation of the non-actomyosin component of aortic wall contraction by phorbol ester. Biochem Biophys Res Commun., 1994; 199(2):944-8.
Edith Bulbring and a list of her closest colleagues, among which M.F. Shuba is mentioned

High international reputation of the Department in smooth muscle research was greatly further fostered by the work of M.F. Shuba in the laboratory of the world's most renowned scientist in the field of smooth muscle physiology, Prof. Edith Bulbring, in Oxford during 1973-74, and conducting in October 1974 in Kyiv on the basis of Department of extremely representative international symposium, summing all the achievements to that period in the study of smooth muscles.

Students and associated of the Department: Dr. I.A. Vladimirova (1934-2015), Prof. A. Zholos, Dr. D. Gordienko, Dr. V.Y. Ganitkevich (1957-2014), Dr. S. Smirnov, Dr. A.V. Zima, Dr. I.B. Filippov and others, duly took over a high level of smooth muscle research, set up in the Department, and successfully transferred it to new places of their scientific activity.

Its modern appearance the Department acquired in 2007 after merging with the Laboratory of Biophysics of Ion Channels, headed by Prof. Yaroslav M. Shuba, who simultaneously became the new chair of the Department. Merger with the laboratory and inclusion of new personnel led to some reformatting of scientific subjects of the Department towards greater emphasis on directions related to the biophysical properties of ion channels and their role in pathological processes. These directions were:

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